Publications by Costantino Grana

Large-scale benchmarks such as BraTS have driven progress in brain tumor segmentation, but they provide only masks with limited access to the clinical semantics found in radiology reports. We introduce ReportX, a paired resource of 257 clinical reports aligned to BraTS-GLI-2023 subjects, structured into a rich set of qualitative and quantitative attributes. Qualitative fields are curated by clinicians, while quantitative descriptors are automatically derived via atlas-based localization and geometric computations. We compare our annotation schema to existing report-augmented datasets and show that ReportX provides substantially broader coverage of clinically relevant factors. To exploit this supervision, we encode reports using biomedical language models and incorporate their embeddings as auxiliary semantic guidance for 3D tumor segmentation during training. Experimental results demonstrate that the proposed vision-text alignment improves segmentation performance on standard BraTS metrics, with clinically curated reports providing more consistent improvements than automatically generated or less-structured counterparts. We publicly release the dataset (https://ditto.ing.unimore.it/reportx) and the source code (https://github.com/AImageLab-zip/ReportX).

Reproducibility policies promise "checkable" medical-imaging science, yet many submissions still ship unverifiable artifacts. Our analysis of 3722 MICCAI papers shows code-linking rising from 51.8% (2021) to 72.5% (2025), but ~13% of linked repositories are inaccessible or empty. We present paper-snitch, a reviewer-facing decision-support tool that turns these signals into an evidence-grounded report. Paper-snitch parses PDFs, resolves and sanity-checks repositories, and applies policy-aware checklists aligned with MICCAI expectations, producing a review-time verifiability score decomposed into interpretable sub-scores plus criterion-linked excerpts and artifacts reviewers can inspect. It never executes untrusted code or attempts GPU-heavy reproduction, focusing instead on bounded, verifiable checks. We compare paper-snitch on 100 randomly sampled MICCAI 2025 papers with human annotators using shared evaluation criteria, indicating that automated, bounded checks can scale reproducibility screening while keeping final decisions with reviewers.

Accurate delineation of maxillofacial anatomy in Cone-Beam Computed Tomography (CBCT) is essential for dental planning, but robust automated segmentation remains challenging, due to limited public multi-structure datasets and the high computational burden of 3D deep learning models. We present and release ToothFairy3, a large-scale CBCT benchmark that extends ToothFairy2 with 102 additional fully annotated scans and an expanded taxonomy covering 77 classes, including 32 tooth-specific pulp cavities and small neurovascular structures. ToothFairy3 comprises 582 volumes (over 40000 annotated objects), with 532 released with voxel-level labels and 50 held out for leakage-free, server-side evaluation. We also introduce U-Mamba2, an efficient U-Net-style architecture that inserts a Mamba2 state-space block at the bottleneck to capture global context with favorable computational scaling. Our proposed domain-informed training further improves the learning of maxillofacial anatomies. Across CNN, Transformer, and Mamba baselines, U-Mamba2 achieves competitive Dice/HD95 scores with lower latency and, compared with training on state-of-the-art public CBCT datasets, ToothFairy3-trained models generalize best to the hidden test set, particularly for maxillary structures.

Barcodes are a critical technology in industrial automation, logistics, and retail, enabling fast and reliable data capture. While deep learning has significantly improved barcode localization accuracy, most modern architectures remain too computationally demanding for real-time deployment on embedded systems without dedicated hardware acceleration. In this work, we present BaFaLo (Barcode Fast Localizer), an ultra-lightweight segmentation-based neural network for barcode localization. Our model is specifically optimized for real-time performance on low-power CPUs while maintaining high localization accuracy for both 1D and 2D barcodes. It features a two-branch architecture—comprising a local feature extractor and a global context module—and is tailored for low-resolution inputs to improve inference speed further. We benchmark BaFaLo against several lightweight architectures for object detection or segmentation, including YOLO Nano, Fast-SCNN, BiSeNet V2, and ContextNet, using the BarBeR dataset. BaFaLo achieves the fastest inference time among all deep-learning models tested, operating at 57.62ms per frame on a single CPU core of a Raspberry Pi 3B+. Despite its compact design, it achieves a decoding rate nearly equivalent to YOLO Nano for 1D barcodes and only 3.5 percentage points lower for 2D barcodes while being approximately nine times faster.

CNNs and Transformer-based architectures are recently dominating the field of 3D medical segmentation. While CNNs face limitations in the local receptive field, Transformers require significant memory and data, making them less suitable for analyzing large 3D medical volumes. Consequently, fully convolutional network models like U-Net are still leading the 3D segmentation scenario. Although efforts have been made to reduce the Transformers computational complexity, such optimized models still struggle with content-based reasoning. This paper examines Mamba, a Recurrent Neural Network (RNN) based on State Space Models (SSMs), which achieves linear complexity and has outperformed Transformers in long-sequence tasks. Specifically, we assess Mamba’s performance in 3D medical segmentation using three widely recognized and commonly employed datasets and propose architectural enhancements to improve its segmentation effectiveness by mitigating the primary shortcomings of existing Mamba-based solutions.

This paper provides a detailed description of how to install, set up, and use "BarBeR" (Barcode Benchmark Repository) to reproduce the results presented in the ICPR 2024 paper "BarBeR: A Barcode Benchmarking Repository". The paper details the tests available in the repository and how the configuration parameters affect and influence experimental results.

Since their invention in 1949, barcodes have remained the preferred method for automatic data capture, playing a crucial role in supply chain management. To detect a barcode in an image, multiple algorithms have been proposed in the literature, with a significant increase of interest in the topic since the rise of deep learning. However, research in the field suffers from many limitations, including the scarcity of public datasets and code implementations, which hampers the reproducibility and reliability of published results. For this reason, we developed "BarBeR" (Barcode Benchmark Repository), a benchmark designed for testing and comparing barcode detection algorithms. This benchmark includes the code implementation of various detection algorithms for barcodes, along with a suite of useful metrics. It offers a range of test setups and can be expanded to include any localization algorithm. In addition, we provide a large, annotated dataset of 8748 barcode images, combining multiple public barcode datasets with standardized annotation formats for both detection and segmentation tasks. Finally, we share the results obtained from running the benchmark on our dataset, offering valuable insights into the performance of different algorithms.

We introduce Bits2Bites, the first publicly available dataset for occlusal classification from intra-oral scans, comprising 200 paired upper and lower dental arches annotated across multiple clinically relevant dimensions (sagittal, vertical, transverse, and midline relationships). Leveraging this resource, we propose a multi-task learning benchmark that jointly predicts five occlusal traits from raw 3D point clouds using state-of-the-art point-based neural architectures. Our approach includes extensive ablation studies assessing the benefits of multi-task learning against single-task baselines, as well as the impact of automatically-predicted anatomical landmarks as input features. Results demonstrate the feasibility of directly inferring comprehensive occlusion information from unstructured 3D data, achieving promising performance across all tasks. Our entire dataset, code, and pretrained models are publicly released to foster further research in automated orthodontic diagnosis.

Testicular ultrasound imaging is vital for assessing male infertility, with testicular inhomogeneity serving as a key biomarker. However, subjective interpretation and the scarcity of publicly available datasets pose challenges to automated classification. In this study, we explore supervised and unsupervised pretraining strategies using a ResNet-based architecture, supplemented by diffusion-based generative models to synthesize realistic ultrasound images. Our results demonstrate that pretraining significantly enhances classification performance compared to training from scratch, and synthetic data can effectively substitute real images in the pretraining process, alleviating data-sharing constraints. These methods offer promising advancements toward robust, clinically valuable automated analysis of male infertility. The source code is publicly available at https://github.com/AImageLab-zip/TesticulUS/.

Convolutional Neural Networks (CNNs) have been broadly employed in dermoscopic image analysis, mainly due to the large amount of data gathered by the International Skin Imaging Collaboration (ISIC). But where do neural networks look? Several authors have claimed that the ISIC dataset is affected by strong biases, i.e. spurious correlations between samples that machine learning models unfairly exploit while discarding the useful patterns they are expected to learn. These strong claims have been supported by showing that deep learning models maintain excellent performance even when "no information about the lesion remains" in the debased input images. With this paper, we explore the interpretability of CNNs in dermoscopic image analysis by analyzing which characteristics are considered by autonomous classification algorithms. Starting from a standard setting, experiments presented in this paper gradually conceal well-known crucial dermoscopic features and thoroughly investigate how CNNs performance subsequently evolves. Experimental results carried out on two well-known CNNs, EfficientNet-B3, and ResNet-152, demonstrate that neural networks autonomously learn to extract features that are notoriously important for melanoma detection. Even when some of such features are removed, the others are still enough to achieve satisfactory classification performance. Obtained results demonstrate that literature claims on biases are not supported by carried-out experiments. Finally, to demonstrate the generalization capabilities of state-of-the-art CNN models for skin lesion classification, a large private dataset has been employed as an additional test set.