Publications by Elisa Ficarra
Explore our research publications: papers, articles, and conference proceedings from AImageLab.
Novel Method for MicroRNA Target Prediction Using a Genetic Algorithm
Authors: Reyes Herrera, Paula Helena; Acquaviva, Andrea; Ficarra, Elisa; Macii, Enrico
Automated Discrimination of Pathological Regions in Tissue Images: Unsupervised Clustering vs Supervised SVM Classification
Authors: Di Cataldo, Santa; Ficarra, Elisa; Macii, Enrico
Published in: COMMUNICATIONS IN COMPUTER AND INFORMATION SCIENCE
Recognizing and isolating cancerous cells from non pathological tissue areas (e.g. connective stroma) is crucial for fast and objective immunohistochemical … (Read full abstract)
Recognizing and isolating cancerous cells from non pathological tissue areas (e.g. connective stroma) is crucial for fast and objective immunohistochemical analysis of tissue images. This operation allows the further application of fully-automated techniques for quantitative evaluation of protein activity, since it avoids the necessity of a preventive manual selection of the representative pathological areas in the image, as well as of taking pictures only in the pure-cancerous portions of the tissue. In this paper we present a fully-automated method based on unsupervised clustering that performs tissue segmentations highly comparable with those provided by a skilled operator, achieving on average an accuracy of 90%. Experimental results on a heterogeneous dataset of immunohistochemical lung cancer tissue images demonstrate that our proposed unsupervised approach overcomes the accuracy of a theoretically superior supervised method such as Support Vector Machine (SVM) by 8%.
Fully-Automated Segmentation of Tumor Areas in Tissue Confocal Images
Authors: Di Cataldo, Santa; Ficarra, Elisa; Macii, Enrico
Bioimaging and Clinical Genomics
Authors: Ficarra, E.; De Micheli, G.; Yoon, S.; Benini, L.; Macii, E.