Publications

Nowadays, single-cell DNA (sc-DNA) sequencing is showing up to be a valuable instrument to investigate intra and inter-tumor heterogeneity and infer its evolutionary dynamics, by using the high-resolution data it produces. That is why the demand for analytical tools to manage this kind of data is increasing. Here we propose a pipeline capable of producing multi-sample copy-number variation (CNV) analysis on large-scale single-cell DNA sequencing data and investigate spatial and temporal tumor heterogeneity.

In order to help cancer researchers in understanding tumor heterogeneity and its evolutionary dynamics, we propose a software pipeline to explore intra-tumor heterogeneity by means of scDNA sequencing data.

This paper presents a novel strategy to perform skin lesion segmentation from dermoscopic images. We design an effective segmentation pipeline, and explore several pre-training methods to initialize the features extractor, highlighting how different procedures lead the Convolutional Neural Network (CNN) to focus on different features. An encoder-decoder segmentation CNN is employed to take advantage of each pre-trained features extractor. Experimental results reveal how multiple initialization strategies can be exploited, by means of an ensemble method, to obtain state-of-the-art skin lesion segmentation accuracy.

We discuss a preliminary investigation on the feasibility of inferring traits of social participation from the observable behaviour of individuals involved in dyadic interactions. Trait inference relies on a stochastic model of the dynamics occurring in the individual core affect state-space. Results obtained on a publicly available interaction dataset are presented and examined.

Nowadays, Vector-Borne Diseases (VBDs) raise a severe threat for public health, accounting for a considerable amount of human illnesses. Recently, several surveillance plans have been put in place for limiting the spread of such diseases, typically involving on-field measurements. Such a systematic and effective plan still misses, due to the high costs and efforts required for implementing it. Ideally, any attempt in this field should consider the triangle vectors-host-pathogen, which is strictly linked to the environmental and climatic conditions. In this paper, we exploit satellite imagery from Sentinel-2 mission, as we believe they encode the environmental factors responsible for the vector's spread. Our analysis - conducted in a data-driver fashion - couples spectral images with ground-truth information on the abundance of Culicoides imicola. In this respect, we frame our task as a binary classification problem, underpinning Convolutional Neural Networks (CNNs) as being able to learn useful representation from multi-band images. Additionally, we provide a multi-instance variant, aimed at extracting temporal patterns from a short sequence of spectral images. Experiments show promising results, providing the foundations for novel supportive tools, which could depict where surveillance and prevention measures could be prioritized.

Cross-modal retrieval has been recently becoming an hot-spot research, thanks to the development of deeply-learnable architectures. Such architectures generally learn a joint multi-modal embedding space in which text and images could be projected and compared. Here we investigate a different approach, and reformulate the problem of cross-modal retrieval as that of learning a translation between the textual and visual domain. In particular, we propose an end-to-end trainable model which can translate text into image features and vice versa, and regularizes this mapping with a cycle-consistency criterion. Preliminary experimental evaluations show promising results with respect to ordinary visual-semantic models.

Abnormal crowd behaviour detection attracts a large interest due to its importance in video surveillance scenarios.However, the ambiguity and the lack of sufficient abnormal ground truth data makes end-to-end training of large deep networks hard in this domain. In this paper we propose to use Generative Adversarial Nets (GANs), which are trained to generate only the normal distribution of the data. During the adversarial GAN training, a discriminator (D) is used as a supervisor for the generator network(G) and vice versa. At testing time we use D to solve our discriminative task (abnormality detection), where D has been trained without the need of manually-annotated abnormal data. Moreover, in order to prevent G learn a trivial identity function, we use a cross-channel approach, forcing G to transform raw-pixel data in motion information and vice versa. The quantitative results on standard benchmarks show that our method outperforms previous state-of-the-art methods in both the frame-level and the pixel-level evaluation.

A classifier trained on a dataset seldom works on other datasets obtained under different conditions due to domain shift. This problem is commonly addressed by domain adaptation methods. In this work we introduce a novel deep learning framework which unifies different paradigms in unsupervised domain adaptation. Specifically, we propose domain alignment layers which implement feature whitening for the purpose of matching source and target feature distributions. Additionally, we leverage the unlabeled target data by proposing the Min-Entropy Consensus loss, which regularizes training while avoiding the adoption of many user-defined hyper-parameters. We report results on publicly available datasets, considering both digit classification and object recognition tasks. We show that, in most of our experiments, our approach improves upon previous methods, setting new state-of-the-art performances.

Event cameras, neuromorphic devices that naturally respond to brightness changes, have multiple advantages with respect to traditional cameras. However, the difficulty of applying traditional computer vision algorithms on event data limits their usability. Therefore, in this paper we investigate the use of a deep learning-based architecture that combines an initial grayscale frame and a series of event data to estimate the following intensity frames. In particular, a fully-convolutional encoder-decoder network is employed and evaluated for the frame synthesis task on an automotive event-based dataset. Performance obtained with pixel-wise metrics confirms the quality of the images synthesized by the proposed architecture.

Visual-semantic embeddings have been extensively used as a powerful model for cross-modal retrieval of images and sentences. In this setting, data coming from different modalities can be projected in a common embedding space, in which distances can be used to infer the similarity between pairs of images and sentences. While this approach has shown impressive performances on fully supervised settings, its application to semi-supervised scenarios has been rarely investigated. In this paper we propose a domain adaptation model for cross-modal retrieval, in which the knowledge learned from a supervised dataset can be transferred on a target dataset in which the pairing between images and sentences is not known, or not useful for training due to the limited size of the set. Experiments are performed on two target unsupervised scenarios, respectively related to the fashion and cultural heritage domain. Results show that our model is able to effectively transfer the knowledge learned on ordinary visual-semantic datasets, achieving promising results. As an additional contribution, we collect and release the dataset used for the cultural heritage domain.