Publications

Here we introduce an approximated differentiable renderer to refine a 6-DoF pose prediction using only 2D alignment information. To this end, a two-branched convolutional encoder network is employed to jointly estimate the object class and its 6-DoF pose in the scene. We then propose a new formulation of an approximated differentiable renderer to re-project the 3D object on the image according to its predicted pose; in this way the alignment error between the observed and the re-projected object silhouette can be measured. Since the renderer is differentiable, it is possible to back-propagate through it to correct the estimated pose at test time in an online learning fashion. Eventually we show how to leverage the classification branch to profitably re-project a representative model of the predicted class (i.e. a medoid) instead. Each object in the scene is processed independently and novel viewpoints in which both objects arrangement and mutual pose are preserved can be rendered. Differentiable renderer code is available at:https://github.com/ndrplz/tensorflow-mesh-renderer.

Nowadays, Vector-Borne Diseases (VBDs) raise a severe threat for public health, accounting for a considerable amount of human illnesses. Recently, several surveillance plans have been put in place for limiting the spread of such diseases, typically involving on-field measurements. Such a systematic and effective plan still misses, due to the high costs and efforts required for implementing it. Ideally, any attempt in this field should consider the triangle vectors-host-pathogen, which is strictly linked to the environmental and climatic conditions. In this paper, we exploit satellite imagery from Sentinel-2 mission, as we believe they encode the environmental factors responsible for the vector's spread. Our analysis - conducted in a data-driver fashion - couples spectral images with ground-truth information on the abundance of Culicoides imicola. In this respect, we frame our task as a binary classification problem, underpinning Convolutional Neural Networks (CNNs) as being able to learn useful representation from multi-band images. Additionally, we provide a multi-instance variant, aimed at extracting temporal patterns from a short sequence of spectral images. Experiments show promising results, providing the foundations for novel supportive tools, which could depict where surveillance and prevention measures could be prioritized.

The early diagnosis of colorectal cancer (CRC) traditionally leverages upon the microscopic examination of histological slides by experienced pathologists, which is very time-consuming and rises many issues about the reliability of the results. In this paper we propose using Convolutional Neural Networks (CNNs), a class of deep networks that are successfully used in many contexts of pattern recognition, to automatically distinguish the cancerous tissues from either healthy or benign lesions. For this purpose, we designed and compared different CNN-based classification frameworks, involving either training CNNs from scratch on three classes of colorectal images, or transfer learning from a different classification problem. While a CNN trained from scratch obtained very good (about 90%) classification accuracy in our tests, the same CNN model pre-trained on the ImageNet dataset obtained even better accuracy (around 96%) on the same testing samples, requiring much lesser computational resources.

In this paper the problem of Connected Components Labeling (CCL) in binary images using Graphic Processing Units (GPUs) is tackled by a different perspective. In the last decade, many novel algorithms have been released, specifically designed for GPUs. Because CCL literature concerning sequential algorithms is very rich, and includes many efficient solutions, designers of parallel algorithms were often inspired by techniques that had already proved successful in a sequential environment, such as the Union-Find paradigm for solving equivalences between provisional labels. However, the use of decision trees to minimize memory accesses, which is one of the main feature of the best performing sequential algorithms, was never taken into account when designing parallel CCL solutions. In fact, branches in the code tend to cause thread divergence, which usually leads to inefficiency. Anyway, this consideration does not necessarily apply to every possible scenario. Are we sure that the advantages of decision trees do not compensate for the cost of thread divergence? In order to answer this question, we chose three well-known sequential CCL algorithms, which employ decision trees as the cornerstone of their strategy, and we built a data-parallel version of each of them. Experimental tests on real case datasets show that, in most cases, these solutions outperform state-of-the-art algorithms, thus demonstrating the effectiveness of decision trees also in a parallel environment.

Dense optical flow estimation is complex and time consuming, with state-of-the-art methods relying either on large synthetic data sets or on pipelines requiring up to a few minutes per frame pair. In this paper, we address the problem of optical flow estimation in the automotive scenario in a self-supervised manner. We argue that optical flow can be cast as a geometrical warping between two successive video frames and devise a deep architecture to estimate such transformation in two stages. First, a dense pixel-level flow is computed with a projective bootstrap on rigid surfaces. We show how such global transformation can be approximated with a homography and extend spatial transformer layers so that they can be employed to compute the flow field implied by such transformation. Subsequently, we refine the prediction by feeding a second, deeper network that accounts for moving objects. A final reconstruction loss compares the warping of frame Xₜ with the subsequent frame Xₜ₊₁ and guides both estimates. The model has the speed advantages of end-to-end deep architectures while achieving competitive performances, both outperforming recent unsupervised methods and showing good generalization capabilities on new automotive data sets.

Approximately 18% of acute myeloid leukemia (AML) cases express a fusion transcript. However, few fusions are recurrent across AML and the identification of these rare chimeras is of interest to characterize AML patients. Here, we studied the transcriptome of 8 adult AML patients with poorly described chromosomal translocation(s), with the aim of identifying novel and rare fusion transcripts. We integrated RNA-sequencing data with multiple approaches including computational analysis, Sanger sequencing, fluorescence in situ hybridization and in vitro studies to assess the oncogenic potential of the ZEB2-BCL11B chimera. We detected 7 different fusions with partner genes involving transcription factors (OAZ-MAFK, ZEB2-BCL11B), tumor suppressors (SAV1-GYPB, PUF60-TYW1, CNOT2-WT1) and rearrangements associated with the loss of NF1 (CPD-PXT1, UTP6-CRLF3). Notably, ZEB2-BCL11B rearrangements co-occurred with FLT3 mutations and were associated with a poorly differentiated or mixed phenotype leukemia. Although the fusion alone did not transform murine c-Kit+ bone marrow cells, 45.4% of 14q32 non-rearranged AML cases were also BCL11B-positive, suggesting a more general and complex mechanism of leukemogenesis associated with BCL11B expression. Overall, by combining different approaches, we described rare fusion events contributing to the complexity of AML and we linked the expression of some chimeras to genomic alterations hitting known genes in AML.

Thanks to their capability to learn generalizable descriptors directly from images, deep Convolutional Neural Networks (CNNs) seem the ideal solution to most pattern recognition problems. On the other hand, to learn the image representation, CNNs need huge sets of annotated samples that are unfeasible in many every-day scenarios. This is the case, for example, of Computer-Aided Diagnosis (CAD) systems for digital pathology, where additional challenges are posed by the high variability of the cancerous tissue characteristics. In our experiments, state-of-the-art CNNs trained from scratch on histological images were less accurate and less robust to variability than a traditional machine learning framework, highlighting all the issues of fully training deep networks with limited data from real patients. To solve this problem, we designed and compared three transfer learning frameworks, leveraging CNNs pre-trained on non-medical images. This approach obtained very high accuracy, requiring much less computational resource for the training. Our findings demonstrate that transfer learning is a solution to the automated classification of histological samples and solves the problem of designing accurate and computationally-efficient CAD systems with limited training data.

The applicability of computer vision to real paintings and artworks has been rarely investigated, even though a vast heritage would greatly benefit from techniques which can understand and process data from the artistic domain. This is partially due to the small amount of annotated artistic data, which is not even comparable to that of natural images captured by cameras. In this paper, we propose a semantic-aware architecture which can translate artworks to photo-realistic visualizations, thus reducing the gap between visual features of artistic and realistic data. Our architecture can generate natural images by retrieving and learning details from real photos through a similarity matching strategy which leverages a weakly-supervised semantic understanding of the scene. Experimental results show that the proposed technique leads to increased realism and to a reduction in domain shift, which improves the performance of pre-trained architectures for classification, detection, and segmentation. Code is publicly available at: https://github.com/aimagelab/art2real.